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Article

Fitness Tradeoffs of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli.

Genome biology and evolution - 1 Feb 2018

Basra Prabh, Alsaadi Ahlam, Bernal-Astrain Gabriela, O'Sullivan Michael Liam, Hazlett Bryn, Clarke Leah Marie, Schoenrock Andrew, Pitre Sylvain, Wong Alex

Abstract excerpt

Evolutionary trade-offs occur when selection on one trait has detrimental effects on other traits. In pathogenic microbes, it has been hypothesized that antibiotic resistance trades off with fitness in the absence of antibiotic. Although studies of single resistance mutations support this hypothesis, it is unclear whether trade-offs are maintained over time, due to compensatory evolution and broader effects of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29432584
DOI: 10.1093/gbe/evy030
PMCID: PMC5817949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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