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Article

Recent advances in animal and human pluripotent stem cell modeling of cardiac laminopathy.

Stem cell research & therapy - 20 Sept 2016

Lee Yee-Ki, Jiang Yu, Ran Xin-Ru, Lau Yee-Man, Ng Kwong-Man, Lai Wing-Hon Kevin, Siu Chung-Wah, Tse Hung-Fat

Abstract excerpt

Laminopathy is a disease closely related to deficiency of the nuclear matrix protein lamin A/C or failure in prelamin A processing, and leads to accumulation of the misfold protein causing progeria. The resultant disrupted lamin function is highly associated with abnormal nuclear architecture, cell senescence, apoptosis, and unstable genome integrity. To date, the effects of loss in nuclear integrity on the...

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Share to Cardiomyopathy, Dilated
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Conduction System

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Source

Open in PubMed Open full text

Identifiers

PMID: 27649756
DOI: 10.1186/s13287-016-0401-5
PMCID: PMC5029055

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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