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Article

Improving SNP prioritization and pleiotropic architecture estimation by incorporating prior knowledge using graph-GPA.

Bioinformatics (Oxford, England) - 15 Jun 2018

Kim Hang J, Yu Zhenning, Lawson Andrew, Zhao Hongyu, Chung Dongjun

Abstract excerpt

Summary: Integration of genetic studies for multiple phenotypes is a powerful approach to improving the identification of genetic variants associated with complex traits. Although it has been shown that leveraging shared genetic basis among phenotypes, namely pleiotropy, can increase statistical power to identify risk variants, it remains challenging to effectively integrate genome-wide association study (GWAS)...

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PMID: 29432514
DOI: 10.1093/bioinformatics/bty061
PMCID: PMC6248798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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