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Article

CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes.

Cancer research - 15 Apr 2018

Jung Younghun, Cackowski Frank C, Yumoto Kenji, Decker Ann M, Wang Jingcheng, Kim Jin Koo, Lee Eunsohl, Wang Yugang, Chung Jae-Seung, Gursky Amy M, Krebsbach Paul H, Pienta Kenneth J, Morgan Todd M, Taichman Russell S

Abstract excerpt

There is evidence that cancer stem-like cells (CSC) and neuroendocrine behavior play critical roles in the pathogenesis and clinical course of metastatic castration-resistant prostate cancer (m-CRPC). However, there is limited mechanistic understanding of how CSC and neuroendocrine phenotypes impact the development of m-CRPC. In this study, we explored the role of the intracellular chemokine CXCL12γ in CSC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29431639
DOI: 10.1158/0008-5472.CAN-17-2332
PMCID: PMC6324566

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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