Article
Defining a Population of Stem-like Human Prostate Cancer Cells That Can Generate and Propagate Castration-Resistant Prostate Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2016
Chen Xin, Li Qiuhui, Liu Xin, Liu Can, Liu Ruifang, Rycaj Kiera, Zhang Dingxiao, Liu Bigang, Jeter Collene, Calhoun-Davis Tammy, Lin Kevin, Lu Yue, Chao Hsueh-Ping, Shen Jianjun, Tang Dean G
Abstract excerpt
PURPOSE: We have shown that the phenotypically undifferentiated (PSA(-/lo)) prostate cancer cell population harbors long-term self-renewing cancer stem cells (CSC) that resist castration, and a subset of the cells within the PSA(-/lo) population bearing the ALDH(hi)CD44(+)α2β1(+) phenotype (Triple Marker(+)/TM(+)) is capable of robustly initiating xenograft tumors in castrated mice. The goal of the current...
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