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Article

Stem-Like Cells with Luminal Progenitor Phenotype Survive Castration in Human Prostate Cancer

23 Mar 2012

Abstract excerpt

Castration is the standard therapy for advanced prostate cancer (PC). Although this treatment is initially effective, tumors invariably relapse as incurable, castration-resistant PC (CRPC). Adaptation of androgen-dependent PC cells to an androgen-depleted environment or selection of pre-existing, CRPC cells have been proposed as mechanisms of CRPC development. Stem cell (SC)-like PC cells have been implicated not...

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PMID: 22438320
DOI: 10.1002/stem.1087

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