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Article

A basal stem cell signature identifies aggressive prostate cancer phenotypes.

Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2015

Smith Bryan A, Sokolov Artem, Uzunangelov Vladislav, Baertsch Robert, Newton Yulia, Graim Kiley, Mathis Colleen, Cheng Donghui, Stuart Joshua M, Witte Owen N

Abstract excerpt

Evidence from numerous cancers suggests that increased aggressiveness is accompanied by up-regulation of signaling pathways and acquisition of properties common to stem cells. It is unclear if different subtypes of late-stage cancer vary in stemness properties and whether or not these subtypes are transcriptionally similar to normal tissue stem cells. We report a gene signature specific for human prostate basal...

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Share to Epithelial Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Glands, Human

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Source

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Identifiers

PMID: 26460041
DOI: 10.1073/pnas.1518007112
PMCID: PMC4664352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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