Article
Species-dependent in polymyxin B heteroresistance: genomic insights into adaptive evolution in Enterobacteriaceae.
Annals of clinical microbiology and antimicrobials - 24 Mar 2026
Zhang Hui, Xu Linna, Mo Xiaofen, Tang Biao, Fan Junfeng, Xiao Tingting, Luo Qixia, Wan Fen
Abstract excerpt
BACKGROUND: Polymyxin heteroresistance poses a growing challenge in antimicrobial resistance management, yet its epidemiological features and molecular basis across different bacterial species and environments remain poorly understood. This study aimed to systematically evaluate the prevalence and genomic mechanisms of heteroresistance in Escherichia coli and Klebsiella pneumoniae. METHODS: A total of 416...
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