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Article

Novel polymyxin-resistant Klebsiella pneumoniae with ten resistance determinants and associated mutations drive localized outbreaks.

Journal of infection and public health - 1 Jul 2026

Yuan Kaixuan, Zhang Jiao, Qin Yurong, Yang Xinyue, Zhang Ni, Ling Yong, Liu Xinyi, Zhou Jingfang, Yu Yixi, Ge Shuyue, Liu Weijiang, Liao Yiwen, Chen Huimin, Wang Weisha, Chen Xiaoli, Liu XiaoXiao, Liu Suling, Zhao Yunhu

Abstract excerpt

OBJECTIVE: To characterize the genomic features, resistance mechanisms and potential transmission chains of polymyxin-resistant Klebsiella pneumoniae (PR-KP). METHODS: PR-KP isolates were retrospectively recovered from clinical specimens. Whole-genome sequencing (WGS) was performed, and transmission single-nucleotide polymorphism (SNP) profiling and core-genome phylogenetic analysis were used to reconstruct...

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PMID: 42143544
DOI: 10.1016/j.jiph.2026.103255

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