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Article

Genetic Diversity of Polymyxin Resistance Genes in Klebsiella pneumoniae Clinical Isolates.

Molecular ecology - 1 Jan 2026

Serwy Daniel Miceli, Conde Maria Eduarda Rocha, Alencar Ana Luiza Carneiro, Novaes Roberto Leonan Morim, Lima-Junior Josué da Costa, da Mota Fabio Faria, Carvalho-Assef Ana Paula, Galvao Teca Calcagno, Zahner Viviane

Abstract excerpt

This study investigates the genetic diversity and evolutionary mechanisms driving polymyxin resistance in Klebsiella pneumoniae, a critical priority pathogen. By analysing mgrB, phoPQ and pmrAB genes in susceptible (PM-S) and resistant (PM-R) populations through neutrality tests (Tajima D, Fu & Li's D) we uncovered polygenic adaptation and positive selection as a key driver of resistance. High genetic diversity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41556155
DOI: 10.1111/mec.70234
PMCID: PMC12817155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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