Associations of Bcl-2 rs956572 genotype groups in the structural covariance network in early-stage Alzheimer's disease.

doi:10.1186/s13195-018-0344-4

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Associations of Bcl-2 rs956572 genotype groups in the structural covariance network in early-stage Alzheimer's disease.

Alzheimer's research & therapy - 8 Feb 2018

Chang Chiung-Chih, Chang Ya-Ting, Huang Chi-Wei, Tsai Shih-Jen, Hsu Shih-Wei, Huang Shu-Hua, Lee Chen-Chang, Chang Wen-Neng, Lui Chun-Chung, Lien Chia-Yi

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a complex neurodegenerative disease, and genetic differences may mediate neuronal degeneration. In humans, a single-nucleotide polymorphism in the B-cell chronic lymphocytic leukemia/lymphoma-2 (Bcl-2) gene, rs956572, has been found to significantly modulate Bcl-2 protein expression in the brain. The Bcl-2 AA genotype has been associated with reduced Bcl-2 levels and lower...

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PMID: 29422088
DOI: 10.1186/s13195-018-0344-4
PMCID: PMC5806294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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