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Article

Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer's disease.

Oncotarget - 23 Aug 2016

Lin Pin-Hsuan, Tsai Shih-Jen, Huang Chi-Wei, Mu-En Liu, Hsu Shih-Wei, Lee Chen-Chang, Chen Nai-Ching, Chang Ya-Ting, Lan Min-Yu, Chang Chiung-Chih

Abstract excerpt

In humans, brain-derived neurotrophic factor (BDNF) has been shown to play a pivotal role in neurocognition, and its gene contains a functional polymorphism (Val66Met) that may explain individual differences in brain volume and memory-related activity.In this study, we enrolled 186 Alzheimer's disease (AD) patients who underwent 3D T1 magnetic resonance imaging, and explored the gray matter (GM) structural...

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Source

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Identifiers

PMID: 27494844
DOI: 10.18632/oncotarget.11027
PMCID: PMC5342335

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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