Catechol-O-Methyltransferase Val158Met Polymorphism on Striatum Structural Covariance Networks in Alzheimer's Disease.

doi:10.1007/s12035-017-0668-2

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Catechol-O-Methyltransferase Val158Met Polymorphism on Striatum Structural Covariance Networks in Alzheimer's Disease.

Molecular neurobiology - 1 Jun 2018

Chang Chiung-Chih, Tsai Shih-Jen, Chen Nai-Ching, Huang Chi-Wei, Hsu Shih-Wei, Chang Ya-Ting, Liu Mu-En, Chang Wen-Neng, Tsai Wan-Chen, Lee Chen-Chang

Abstract excerpt

The catechol-O-methyltransferase enzyme metabolizes dopamine in the prefrontal axis, and its genetic polymorphism (rs4680; Val158Met) is a known determinant of dopamine signaling. In this study, we investigated the possible structural covariance networks that may be modulated by this functional polymorphism in patients with Alzheimer's disease. Structural covariance networks were constructed by 3D T1 magnetic...

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PMID: 28707072
DOI: 10.1007/s12035-017-0668-2
PMCID: PMC5948254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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