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Article

Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins

2 Feb 2018

Abstract excerpt

Autophagy is a conserved eukaryotic process with metabolic, immune, and general homeostatic functions in mammalian cells. Mammalian autophagosomes fuse with lysosomes in a SNARE-driven process that includes syntaxin 17 (Stx17). How Stx17 translocates to autophagosomes is unknown. In this study, we show that the mechanism of Stx17 recruitment to autophagosomes in human cells entails the small guanosine...

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PMID: 29420192
DOI: 10.1083/jcb.201708039

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