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Phosphoribosyl ubiquitination of SNARE proteins regulates autophagy during Legionella infection

12 Jun 2025

Abstract excerpt

Legionella pneumophila is an intracellular pathogen that causes Legionnaires' disease. The bacteria release effector proteins, some of which remodel host autophagic-lysosomal pathways. One such effector is RavZ, which delipidates ATG8 proteins, making compromising autophagy in Legionella-infected cells. Here we show that SidE effectors also affect these pathways, by mediating phosphoribosyl-ubiquitination (PR-Ub)...

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PMID: 40506485
DOI: 10.1038/s44318-025-00483-4

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