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Article

Accumulation of undegraded autophagosomes by expression of dominant-negative STX17 (syntaxin 17) mutants.

Autophagy - 3 Aug 2017

Uematsu Masaaki, Nishimura Taki, Sakamaki Yuriko, Yamamoto Hayashi, Mizushima Noboru

Abstract excerpt

Macroautophagy/autophagy, which is one of the main degradation systems in the cell, is mediated by a specialized organelle, the autophagosome. Purification of autophagosomes before fusion with lysosomes is important for both mechanistic and physiological studies of the autophagosome. Here, we report a simple method to accumulate undigested autophagosomes. Overexpression of the autophagosomal Qa-SNARE STX17...

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Source

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Identifiers

PMID: 28598244
DOI: 10.1080/15548627.2017.1327940
PMCID: PMC5584865

Genes

STX17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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