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Article

Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Aug 2022

Goswami Apeksha Bharatgiri, Karadarević Dimitrije, Castaño-Rodríguez Natalia

Abstract excerpt

The human immunity-related GTPase M (IRGM) is a GTP-binding protein that regulates selective autophagy including xenophagy and mitophagy. IRGM impacts autophagy by (1) affecting mitochondrial fusion and fission, (2) promoting the co-assembly of ULK1 and Beclin 1, (3) enhancing Beclin 1 interacting partners (AMBRA1, ATG14L1, and UVRAG), (4) interacting with other key proteins (ATG16L1, p62, NOD2, cGAS, TLR3, and...

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Identifiers

PMID: 35699756
DOI: 10.1007/s00011-022-01595-x
PMCID: PMC9192921

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