Article

RNA Binding of Syntaxin 5 Synergises Membrane Fusion to Accelerate miRNA Export, Activate Macrophage and Clear Pathogens

2023-09-10

Abstract excerpt

Intercellular miRNA exchange acts as a key mechanism to control gene expression post-transcriptionally in mammalian cells. Regulated export of repressive miRNAs allows the expression of inflammatory cytokines in activated macrophages. Intracellular trafficking of miRNAs from endoplasmic reticulum to endosomes is a rate determining step in miRNA export process and plays an important role in controlling cellular miR...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e5928043-45b0-577a-868c-3e8ace35b987
DOI: 10.1101/2023.09.08.556844

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RNA Binding of Syntaxin 5 Synergises Membrane Fusion to Accelerate miRNA Export, Activate Macrophage and Clear PathogensDOI 10.1101/2023.09.08.556844Read

Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteinsSemantic proximity Read

Exosomal MicroRNA-155 Inhibits Enterovirus A71 Infection by Targeting PICALMSemantic proximity Read

Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infectionSemantic proximity Read

Viral miRNAs exploiting the endosomal–exosomal pathway for intercellular cross-talk and immune evasionSemantic proximity Read

Exosomes from EV71‐infected oral epithelial cells can transfer miR‐30a to promote EV71 infectionSemantic proximity Read

Spatiotemporal Uncoupling of MicroRNA-Mediated Translational Repression and Target RNA Degradation Controls MicroRNP Recycling in Mammalian CellsSemantic proximity Read

Small interference RNA profiling reveals the essential role of human membrane trafficking genes in mediating the infectious entry of dengue virusSemantic proximity Read

Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17.Semantic proximity Read

Cytoplasmic short linear motifs in ACE2 and integrin β 3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagySemantic proximity Read

LINC08148 promotes the caveola-mediated endocytosis of Zika virus through upregulating transcription of SrcSemantic proximity Read

Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complexSemantic proximity Read

EMT activates exocytotic Rabs to coordinate invasion and immunosuppression in lung cancerSemantic proximity Read