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Article

Liver X receptor activation stimulates iron export in human alternative macrophages.

Circulation research - 8 Nov 2013

Bories Gaël, Colin Sophie, Vanhoutte Jonathan, Derudas Bruno, Copin Corinne, Fanchon Mélanie, Daoudi Mehdi, Belloy Loïc, Haulon Stephan, Zawadzki Christophe, Jude Brigitte, Staels Bart, Chinetti-Gbaguidi Giulia

Abstract excerpt

RATIONALE: In atherosclerotic plaques, iron preferentially accumulates in macrophages where it can exert pro-oxidant activities. OBJECTIVE: The objective of this study was, first, to better characterize the iron distribution and metabolism in macrophage subpopulations in human atherosclerotic plaques and, second, to determine whether iron homeostasis is under the control of nuclear receptors, such as the liver X...

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Share to Antigens, Differentiation, Myelomonocytic
Share to ATP Binding Cassette Transporter 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily G, Member 1

Share to Liver X Receptors

Share to Mannose-Binding Lectins

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Share to Plaque, Atherosclerotic

Source

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Identifiers

PMID: 24036496
DOI: 10.1161/CIRCRESAHA.113.301656
PMCID: PMC3989231

Genes

ABCA1
ABCG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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