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Article

Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions.

Scientific reports - 7 Feb 2018

Lissina Anna, McLaren James E, Ilander Mette, Andersson Emma I, Lewis Catherine S, Clement Mathew, Herman Andrew, Ladell Kristin, Llewellyn-Lacey Sian, Miners Kelly L, Gostick Emma, Melenhorst J Joseph, Barrett A John, Price David A, Mustjoki Satu, Wooldridge Linda

Abstract excerpt

CD8+ T-cell expansions are the primary manifestation of T-cell large granular lymphocytic leukemia (T-LGLL), which is frequently accompanied by neutropenia and rheumatoid arthritis, and also occur as a secondary phenomenon in leukemia patients treated with dasatinib, notably in association with various drug-induced side-effects. However, the mechanisms that underlie the genesis and maintenance of expanded CD8+...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29416058
DOI: 10.1038/s41598-017-18062-x
PMCID: PMC5803196

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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