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The Value of Flow Cytometry Clonality in Large Granular Lymphocyte Leukemia

8 Sept 2021

Abstract excerpt

Large granular lymphocyte (LGL) leukemia is a lymphoproliferative disorder of mature T or NK cells frequently associated with autoimmune disorders and other hematological conditions, such as myelodysplastic syndromes. Immunophenotype of LGL cells is similar to that of effector memory CD8+ T cells with T-cell receptor (TCR) clonality defined by molecular and/or flow cytometric analysis. Vβ usage by flow cytometry...

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PMID: 34572739
DOI: 10.3390/cancers13184513

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