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Article

Genetic Variation in FOXO3 is Associated with Self-Rated Health in a Population-Based Sample of Older Individuals.

The journals of gerontology. Series A, Biological sciences and medical sciences - 8 Oct 2018

Zettergren Anna, Kern Silke, Rydén Lina, Östling Svante, Blennow Kaj, Zetterberg Henrik, Falk Hanna, Skoog Ingmar

Abstract excerpt

Self-rated health (SRH) strongly predicts mortality. Twin studies estimate that genetic factors account for a substantial part of the variability in SRH. Variations in the gene FOXO3 (forkhead box O3), and in genes located at the APOE (apoplipoprotein E) locus, are associated with longevity. This study explores the relationship between SRH and genetic variation related to longevity, in a population-based cohort...

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Source

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Identifiers

PMID: 29415201
DOI: 10.1093/gerona/gly021
PMCID: PMC6175024

Genes

FOXO3
APOE
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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