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Article

Molecular genetic contributions to self-rated health.

International journal of epidemiology - 1 Jun 2017

Harris Sarah E, Hagenaars Saskia P, Davies Gail, David Hill W, Liewald David C M, Ritchie Stuart J, Marioni Riccardo E, Sudlow Cathie L M, Wardlaw Joanna M, McIntosh Andrew M, Gale Catharine R, Deary Ian J

Abstract excerpt

Background: Poorer self-rated health (SRH) predicts worse health outcomes, even when adjusted for objective measures of disease at time of rating. Twin studies indicate SRH has a heritability of up to 60% and that its genetic architecture may overlap with that of personality and cognition. Methods: We carried out a genome-wide association study (GWAS) of SRH on 111 749 members of the UK Biobank sample. Univariate...

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PMID: 27864402
DOI: 10.1093/ije/dyw219
PMCID: PMC5837683

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