Article
Substantial variation in the hepatitis B surface antigen (HBsAg) in hepatitis B virus (HBV)-positive patients from South Africa: Reliable detection of HBV by the Elecsys HBsAg II assay.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Apr 2018
Gencay Mikael, Vermeulen Marion, Neofytos Dionysis, Westergaard Gaston, Pabinger Stephan, Kriegner Albert, Seffner Anja, Gohl Peter, Huebner Kirsten, Nauck Markus, Kaminski Wolfgang E
Abstract excerpt
BACKGROUND: It is essential that hepatitis B surface antigen (HBsAg) diagnostic assays reliably detect genetic diversity in the major hydrophilic region (MHR) of HBsAg to avoid false-negative results. Mutations in this domain display marked ethno-geographic variation and may lead to failure to diagnose hepatitis B virus (HBV) infection. OBJECTIVES: Evaluate diagnostic performance of the Elecsys® HBsAg II...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.