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Molecular and Serological Characterization of Hepatitis B Virus (HBV)-Positive Samples with Very Low or Undetectable Levels of HBV Surface Antigen.

Viruses - 13 Oct 2021

Kuhns Mary C, Holzmayer Vera, Anderson Mark, McNamara Anne L, Sauleda Silvia, Mbanya Dora, Duong Pham T, Dung Nguyen T T, Cloherty Gavin A

Abstract excerpt

BACKGROUND: Gaps remain in the detection of nucleic acid test (NAT) yield and occult hepatitis B virus (HBV) infection (OBI) by current HBV surface antigen (HBsAg) assays. The lack of detection may be due to HBsAg levels below current assay detection limits, mutations affecting HBsAg assays or HBsAg levels, or the masking of HBsAg by antibody to HBsAg (anti-HBs). In this study, we evaluate the incremental...

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PMID: 34696483
DOI: 10.3390/v13102053
PMCID: PMC8537069

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