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Vesicular monoamine transporter 1 gene polymorphism and white matter integrity in major depressive disorder.

Progress in neuro-psychopharmacology & biological psychiatry - 3 Jul 2017

Won Eunsoo, Han Kyu-Man, Kang June, Kim Aram, Yoon Ho-Kyoung, Chang Hun Soo, Park Ji-Young, Lee Min-Soo, Greenberg Tsafrir, Tae Woo-Suk, Ham Byung-Joo

Abstract excerpt

The genetic variant of the vesicular monoamine transporter 1 gene (VMAT1) has been suggested to be associated with monoaminergic signaling and neural circuit activity related to emotion processing. We aimed to investigate microstructural changes in white matter tracts of patients with major depressive disorder (MDD), and examined the interaction effect between VMAT1 Thr136Ile (rs1390938) polymorphism and MDD on...

Topics

Adult
Aged
Anisotropy
Brain
Case-Control Studies
Depressive Disorder, Major
Diffusion Tensor Imaging
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Male

Middle Aged

Neuroimaging

Polymorphism, Single Nucleotide

Vesicular Monoamine Transport Proteins

White Matter

Young Adult

Source

Identifiers

PMID: 28408293
DOI: 10.1016/j.pnpbp.2017.02.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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