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Article

Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment.

Acta pharmacologica Sinica - 1 Oct 2015

Sun Xiao-xiao, Yu Qiang

Abstract excerpt

Recent studies have revealed extensive genetic and non-genetic variation across different geographical regions of a tumor or throughout different stages of tumor progression, which is referred to as intra-tumor heterogeneity. Several causes contribute to this phenomenon, including genomic instability, epigenetic alteration, plastic gene expression, signal transduction, and microenvironmental differences. These...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to Protein Processing, Post-Translational

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Identifiers

PMID: 26388155
DOI: 10.1038/aps.2015.92
PMCID: PMC4648179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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