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Article

Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes.

Diabetologia - 1 May 2018

Roshandel Delnaz, Gubitosi-Klug Rose, Bull Shelley B, Canty Angelo J, Pezzolesi Marcus G, King George L, Keenan Hillary A, Snell-Bergeon Janet K, Maahs David M, Klein Ronald, Klein Barbara E K, Orchard Trevor J, Costacou Tina, Weedon Michael N, Oram Richard A, Paterson Andrew D

Abstract excerpt

AIMS/HYPOTHESIS: The aim of this study was to identify genetic variants associated with beta cell function in type 1 diabetes, as measured by serum C-peptide levels, through meta-genome-wide association studies (meta-GWAS). METHODS: We performed a meta-GWAS to combine the results from five studies in type 1 diabetes with cross-sectionally measured stimulated, fasting or random C-peptide levels, including 3479...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29404672
DOI: 10.1007/s00125-018-4555-9
PMCID: PMC5876265

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