Article
CTLA-4 +49 G/A, a functional T1D risk SNP, affects CTLA-4 level in Treg subsets and IA-2A positivity, but not beta-cell function.
Scientific reports - 4 Jul 2018
Chen Yang, Chen Shu, Gu Yong, Feng Yingjie, Shi Yun, Fu Qi, Wang Zhixiao, Cai Yun, Dai Hao, Zheng Shuai, Sun Min, Zhang Mei, Xu Xinyu, Chen Heng, Xu Kuanfeng, Yang Tao
Abstract excerpt
To investigate whether CTLA-4 +49 G/A (rs231775), a tagSNP in Asian, is a functional T1D SNP, we genotyped this SNP with 1035 T1D patients and 2575 controls in Chinese Han population. And 1280 controls measured insulin release and sensitivity based on an oral glucose tolerance test; 283 newly diagnosed T1D patients assayed C-peptide level based on a mixed-meal tolerance test. 31 controls were analyzed for...
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