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Article

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function.

Diabetes - 1 Jan 2010

Simonis-Bik Annemarie M, Nijpels Giel, van Haeften Timon W, Houwing-Duistermaat Jeanine J, Boomsma Dorret I, Reiling Erwin, van Hove Els C, Diamant Michaela, Kramer Mark H H, Heine Robert J, Maassen J Antonie, Slagboom P Eline, Willemsen Gonneke, Dekker Jacqueline M, Eekhoff Elisabeth M, de Geus Eco J, 't Hart Leen M

Abstract excerpt

OBJECTIVE: Recently, results from a meta-analysis of genome-wide association studies have yielded a number of novel type 2 diabetes loci. However, conflicting results have been published regarding their effects on insulin secretion and insulin sensitivity. In this study we used hyperglycemic clamps with three different stimuli to test associations between these novel loci and various measures of beta-cell...

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Identifiers

PMID: 19833888
DOI: 10.2337/db09-1048
PMCID: PMC2797936

Genes

ADAMTS9
DCD
JAZF1
NOTCH2
TSPAN8
VEGFA
WFS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function.PMID 19833888Read ↗

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