Cohort profile: the 'Biomarkers of heterogeneity in type 1 diabetes' study-a national prospective cohort study of clinical and metabolic phenotyping of individuals with long-standing type 1 diabetes in the Netherlands.

doi:10.1136/bmjopen-2023-082453

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Cohort profile: the 'Biomarkers of heterogeneity in type 1 diabetes' study-a national prospective cohort study of clinical and metabolic phenotyping of individuals with long-standing type 1 diabetes in the Netherlands.

BMJ open - 19 Jun 2024

Aanstoot Henk-Jan, Varkevisser Rita D M, Mul Dick, Dekker Pim, Birnie Erwin, Boesten Lianne S M, Brugts Michael P, van Dijk Peter R, Duijvestijn Petronella H L M, Dutta Sanjoy, Fransman Christine, Gonera Rob K, Hoogenberg Klaas, Kooy Adriaan, Latres Esther, Loves Sandra, Nefs Giesje, Sas Theo, Vollenbrock Charlotte E, Vosjan-Noeverman Marleen J, de Vries-Velraeds Martine M C, Veeze Henk J, Wolffenbuttel Bruce H R, van der Klauw Melanie M

Abstract excerpt

PURPOSE: The 'Biomarkers of heterogeneity in type 1 diabetes' study cohort was set up to identify genetic, physiological and psychosocial factors explaining the observed heterogeneity in disease progression and the development of complications in people with long-standing type 1 diabetes (T1D). PARTICIPANTS: Data and samples were collected in two subsets. A prospective cohort of 611 participants aged ≥16 years...

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PMID: 38904129
DOI: 10.1136/bmjopen-2023-082453
PMCID: PMC11191834

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