Article
A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes.
eLife - 31 May 2022
Chu Xiaojing, Janssen Anna W M, Koenen Hans, Chang Linzhung, He Xuehui, Joosten Irma, Stienstra Rinke, Kuijpers Yunus, Wijmenga Cisca, Xu Cheng-Jian, Netea Mihai G, Tack Cees J, Li Yang
Abstract excerpt
Background: The large inter-individual variability in immune-cell composition and function determines immune responses in general and susceptibility o immune-mediated diseases in particular. While much has been learned about the genetic variants relevant for type 1 diabetes (T1D), the pathophysiological mechanisms through which these variations exert their effects remain unknown. Methods: Blood samples were...
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