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Article

Formaldehyde induces diabetes-associated cognitive impairments.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2018

Tan Tao, Zhang Yun, Luo Wenhong, Lv Jihui, Han Chanshuai, Hamlin Jason N R, Luo Hongjun, Li Hui, Wan You, Yang Xu, Song Weihong, Tong Zhiqian

Abstract excerpt

Patients with type 2 diabetes mellitus (T2DM) often develop cognitive impairments and have an increased risk of developing Alzheimer's disease. Hyperglycemia is a major characteristic of T2DM, but how elevated glucose levels lead to cognitive decline remains elusive. Here, we report that patients with T2DM and mutations in the formaldehyde (FA)-degrading enzyme aldehyde dehydrogenase 2 ( ALDH2) gene had higher...

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Share to Aldehyde Dehydrogenase, Mitochondrial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

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Share to Mice, Inbred C57BL

Share to Rats, Sprague-Dawley

Source

Identifiers

PMID: 29401634
DOI: 10.1096/fj.201701239R

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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