Article
Association between aldehyde dehydrogenase 2 polymorphisms and the incidence of diabetic retinopathy among Japanese subjects with type 2 diabetes mellitus.
Cardiovascular diabetology - 13 Sept 2013
Morita Kazunori, Saruwatari Junji, Miyagawa Haruna, Uchiyashiki Yoshihiro, Oniki Kentaro, Sakata Misaki, Kajiwara Ayami, Yoshida Akira, Jinnouchi Hideaki, Nakagawa Kazuko
Abstract excerpt
BACKGROUND: Mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies reactive aldehydes in the micro- and macrovasculature. These substrates, including methylglyoxal and 4-hydroxynonenal formed from glucose and lipids, cause protein carbonylation and mitochondrial dysfunction, forming advanced glycation end products (AGEs). The present study aimed to confirm the association between the inactive ALDH2*2 allele...
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