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Ethyl gallate ameliorates diabetes-induced Alzheimer's disease-like phenotype in rats via activation of α7 nicotinic receptors and mitigation of oxidative stress.

Biochemical and biophysical research communications - 10 Dec 2024

Nagori Kushagra, Pradhan Madhulika, Nakhate Kartik T

Abstract excerpt

Cognitive decline, an important comorbidity of type 2 diabetes (T2D), is attributed to oxidative stress and impaired cholinergic signaling in the brain. The α7 nicotinic acetylcholine receptor (α7nAChR) is densely distributed in the hippocampus and cortex, and exerts neuroprotective and procognitive actions. Ethyl gallate (EG), a natural phenolic antioxidant compound, showed high in-silico binding affinity...

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PMID: 39492127
DOI: 10.1016/j.bbrc.2024.150925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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