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Article

Synergistic exacerbation of mitochondrial and synaptic dysfunction and resultant learning and memory deficit in a mouse model of diabetic Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Wang Yongfu, Wu Long, Li Jianping, Fang Du, Zhong Changjia, Chen John Xi, Yan Shirley ShiDu

Abstract excerpt

Diabetes is considered to be a risk factor in Alzheimer's disease (AD) pathogenesis. Although recent evidence indicates that diabetes exaggerates pathologic features of AD, the underlying mechanisms are not well understood. To determine whether mitochondrial perturbation is associated with the contribution of diabetes to AD progression, we characterized mouse models of streptozotocin (STZ)-induced type 1 diabetes...

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Share to Amyloid beta-Protein Precursor
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electron Transport Complex IV

Share to Excitatory Postsynaptic Potentials

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Source

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Identifiers

PMID: 25096625
DOI: 10.3233/JAD-140972
PMCID: PMC4466096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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