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Epigenetic Mechanisms Linking Diabetes and Synaptic Impairments

24 Oct 2013

Abstract excerpt

Diabetes is one of the major risk factors for dementia. However, the molecular mechanism underlying the risk of diabetes for dementia is largely unknown. Recent studies revealed that epigenetic modifications may play a role in the pathogenesis of diabetes. We hypothesized that diabetes may cause epigenetic changes in the brain that may adversely affect synaptic function. We found significant elevation in the...

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PMID: 24154559
DOI: 10.2337/db13-1063

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