Article
Type 2 diabetes aggravates Alzheimer's disease-associated vascular alterations of the aorta in mice.
Journal of Alzheimer's disease : JAD - 1 Jan 2015
Sena Cristina M, Pereira Ana M, Carvalho Cristina, Fernandes Rosa, Seiça Raquel M, Oliveira Catarina R, Moreira Paula I
Abstract excerpt
Vascular risk factors are associated with a higher incidence of dementia. In fact, diabetes mellitus is considered a main risk factor for Alzheimer's disease (AD) and both diseases are characterized by vascular dysfunction. However, the underlying mechanisms remain largely unknown. Here, the effects of high-sucrose-induced type 2 diabetes (T2D) in the aorta of wild type (WT) and triple-transgenic AD (3xTg-AD)...
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