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Article

Human leukocyte antigen alleles associated with inhibitor development in severe hemophilia A: analysis of the "My Life, Our Future" hemophilia A cohort.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2026

Contente Sara, Ahmed Anwar E, Konkle Barbara A, Johnsen Jill M, Frank Andrew, Pratt Kathleen P

Abstract excerpt

BACKGROUND: An earlier analysis of the "My Life, Our Future" Repository indicated the risk of individuals with severe hemophilia A (HA) developing neutralizing antifactor (F)VIII antibodies (inhibitors) was (1) higher in Black and Hispanic cohorts and (2) similar in intron-22 inversion mutations vs other large structural changes in the F8 gene. OBJECTIVES: This study determined whether specific human leukocyte...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41644240
DOI: 10.1016/j.jtha.2025.08.040

Genes

F8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Human leukocyte antigen alleles associated with inhibitor development in severe hemophilia A: analysis of the "My Life, Our Future" hemophilia A cohort.PMID 41644240Read ↗

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F8 and F9 mutations in US haemophilia patients: correlation with history of inhibitor and race/ethnicity.Semantic proximity Read ↗

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Genome-Wide Association Study and Gene-Based Analysis of Participants With Hemophilia A and Inhibitors in the My Life, Our Future Research RepositorySemantic proximity Read ↗

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