<i>In silico</i> calculated affinity of FVIII‐derived peptides for <scp>HLA</scp> class II alleles predicts inhibitor development in haemophilia A patients with missense mutations in the F8 gene

Abstract excerpt

Forty per cent of haemophilia A (HA) patients have missense mutations in the F8 gene. Yet, all patients with identical mutations are not at the same risk of developing factor VIII (FVIII) inhibitors. In severe HA patients, human leucocyte antigen (HLA) haplotype was identified as a risk factor for onset of FVIII inhibitors. We hypothesized that missense mutations in endogenous FVIII alter the affinity of the...

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