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Article

T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus.

Journal of autoimmunity - 1 Jun 2018

Houtman Miranda, Shchetynsky Klementy, Chemin Karine, Hensvold Aase Haj, Ramsköld Daniel, Tandre Karolina, Eloranta Maija-Leena, Rönnblom Lars, Uebe Steffen, Catrina Anca Irinel, Malmström Vivianne, Padyukov Leonid

Abstract excerpt

Non-coding SNPs in the protein tyrosine phosphatase non-receptor type 2 (PTPN2) locus have been linked with several autoimmune diseases, including rheumatoid arthritis, type I diabetes, and inflammatory bowel disease. However, the functional consequences of these SNPs are poorly characterized. Herein, we show in blood cells that SNPs in the PTPN2 locus are highly correlated with DNA methylation levels at four CpG...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29398253
DOI: 10.1016/j.jaut.2018.01.003

Genes

PTPN2
ZEB1

Provenance

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