Article
Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans.
PloS one - 1 Jan 2013
Cobb Joanna E, Plant Darren, Flynn Edward, Tadjeddine Meriem, Dieudé Philippe, Cornélis François, Ärlestig Lisbeth, Dahlqvist Solbritt Rantapää, Goulielmos George, Boumpas Dimitrios T, Sidiropoulos Prodromos, Krintel Sophine B, Ørnbjerg Lykke M, Hetland Merete L, Klareskog Lars, Haeupl Thomas, Filer Andrew, Buckley Christopher D, Raza Karim, Witte Torsten, Schmidt Reinhold E, FitzGerald Oliver, Veale Douglas, Eyre Stephen, Worthington Jane
Abstract excerpt
OBJECTIVES: Genome-wide association studies have facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA). However, evidence for a number of potential susceptibility genes have not so far reached genome-wide significance in studies of Caucasian RA. METHODS: A cohort of 4286 RA patients from across Europe and 5642 population matched controls were genotyped for 25 SNPs, then...
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