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The impact of substrate stiffness on morphological, transcriptional and functional aspects in RPE

29 Mar 2024

Abstract excerpt

Abstract Alterations in the structure and composition of Bruch’s membrane (BrM) and loss of retinal pigment epithelial (RPE) cells are associated with various ocular diseases, notably age-related macular degeneration (AMD) as well as several inherited retinal diseases (IRDs). We explored the influence of stiffness as a major BrM characteristic on the RPE transcriptome and morphology. ARPE-19 cells were plated on...

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PMID: 38553490
DOI: 10.1038/s41598-024-56661-7

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