Article
The role of the methylenetetrahydrofolate reductase 677 and 1298 polymorphisms in Cretan children with acute lymphoblastic leukemia.
Genetic testing and molecular biomarkers - 1 Jan 2000
Karathanasis Nikolaos V, Stiakaki Eftichia, Goulielmos George N, Kalmanti Maria
Abstract excerpt
Acute lymphoblastic leukemia (ALL) is the most common form of malignancy in children. Recently, many studies have examined factors influencing both the susceptibility to ALL and the metabolism of widely used chemotherapeutic agents. These factors include, among others, single-nucleotide polymorphisms in various genes, such as the gene encoding for methylenetetrahydrofolate reductase (MTHFR), which has been proven...
Topics
- Case-Control Studies
- Child
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Greece
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Polymorphism, Genetic