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Article

Metabolomic profiling of pheochromocytomas in dogs: Catecholamine phenotype and tricarboxylic acid cycle metabolites.

Journal of veterinary internal medicine - 1 Jan 2000

van den Berg Marit F, Bechmann Nicole, Kooistra Hans S, van Wolferen Monique E, Timmermans-Sprang Elpetra P M, Peitzsch Mirko, Galac Sara

Abstract excerpt

BACKGROUND: In humans with pheochromocytomas (PCCs), targeted metabolomics is used to determine the catecholamine phenotype or to uncover underlying pathogenic variants in tricarboxylic acid (TCA) cycle genes such as succinate dehydrogenase subunits (SDHx). HYPOTHESIS/OBJECTIVES: To analyze catecholamine contents and TCA cycle metabolites of PCCs and normal adrenals (NAs). ANIMALS: Ten healthy dogs, 21 dogs with...

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PMID: 39115145
DOI: 10.1111/jvim.17148
PMCID: PMC11423489

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