Article
The Pseudomonas aeruginosa ExoY phenotype of high-copy-number recombinants is not detectable in natural isolates.
Open biology - 1 Jan 2018
Munder Antje, Rothschuh Justin, Schirmer Bastian, Klockgether Jens, Kaever Volkhard, Tümmler Burkhard, Seifert Roland, Kloth Christina
Abstract excerpt
The nucleotidyl cyclase ExoY is an effector protein of the type III secretion system of Pseudomonas aeruginosa We compared the cyclic nucleotide production and lung disease phenotypes caused by the ExoY-overexpressing strain PA103ΔexoUexoT::Tc pUCPexoY, its vector control strain PA103ΔexoUexoT::Tc pUCP18, its loss-of-function control PA103ΔexoUexoT::Tc pUCPexoY K81M and natural ExoY-positive and ExoY-negative...
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