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Article

EPS-LASSO: test for high-dimensional regression under extreme phenotype sampling of continuous traits.

Bioinformatics (Oxford, England) - 15 Jun 2018

Xu Chao, Fang Jian, Shen Hui, Wang Yu-Ping, Deng Hong-Wen

Abstract excerpt

Motivation: Extreme phenotype sampling (EPS) is a broadly-used design to identify candidate genetic factors contributing to the variation of quantitative traits. By enriching the signals in extreme phenotypic samples, EPS can boost the association power compared to random sampling. Most existing statistical methods for EPS examine the genetic factors individually, despite many quantitative traits have multiple...

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PMID: 29385408
DOI: 10.1093/bioinformatics/bty042
PMCID: PMC6454442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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