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Article

Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants.

Genetic epidemiology - 1 May 2011

Guey Lin T, Kravic Jasmina, Melander Olle, Burtt Noël P, Laramie Jason M, Lyssenko Valeriya, Jonsson Anna, Lindholm Eero, Tuomi Tiinamaija, Isomaa Bo, Nilsson Peter, Almgren Peter, Kathiresan Sekar, Groop Leif, Seymour Albert B, Altshuler David, Voight Benjamin F

Abstract excerpt

Next-generation sequencing technologies are making it possible to study the role of rare variants in human disease. Many studies balance statistical power with cost-effectiveness by (a) sampling from phenotypic extremes and (b) utilizing a two-stage design. Two-stage designs include a broad-based...

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PMID: 21308769
DOI: 10.1002/gepi.20572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21308769-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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