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GMEPS: a fast and efficient likelihood approach for genome-wide mediation analysis under extreme phenotype sequencing.

Statistical applications in genetics and molecular biology - 11 Mar 2022

Liyanage Janaka S S, Estepp Jeremie H, Srivastava Kumar, Li Yun, Mori Motomi, Kang Guolian

Abstract excerpt

Due to many advantages such as higher statistical power of detecting the association of genetic variants in human disorders and cost saving, extreme phenotype sequencing (EPS) is a rapidly emerging study design in epidemiological and clinical studies investigating how genetic variations associate with complex phenotypes. However, the investigation of the mediation effect of genetic variants on phenotypes is...

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PMID: 35266368
DOI: 10.1515/sagmb-2021-0071

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