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Article

Carboxypeptidase B2 and N play different roles in regulation of activated complements C3a and C5a in mice.

Journal of thrombosis and haemostasis : JTH - 1 May 2018

Morser J, Shao Z, Nishimura T, Zhou Q, Zhao L, Higgins J, Leung L L K

Abstract excerpt

Essentials Two basic carboxypeptidases are present in plasma, B2 (CPB2) and N (CPN). Cpb2-/- and Cpn-/- mice were challenged in a hemolytic uremic syndrome (HUS) model vs. wild type. Cpb2-/- exacerbates HUS while Cpn-/- exacerbates cobra venom factor challenge vs. wild type mice. CPB2 and CPN have overlapping but non-redundant roles. SUMMARY: Background There are two basic carboxypeptidases in plasma....

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Identifiers

PMID: 29383821
DOI: 10.1111/jth.13964
PMCID: PMC8491566

Genes

CPB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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